GDIIST Introduction

The Guangdong Institute of Intelligence Science and Technology (GDIIST) is a provincial non-profit institution established in Guangdong Province. It focuses on multidisciplinary research in cognitive science, artificial intelligence, computer science, information technology and other fields. GDIIST aims to promote the transformation of achievements in brain science, bio-medicine, computational intelligence, information technology and so on.

Group Introduction and Personal Profile

Laboratory of Memory and Cognition

The research is pursued along two lines to explore the mechanisms of learning and memory. One line is focused on different types of glutamate receptors and their intricate regulation by several proteins. Genetically modified zebrafish are generated for behavioural studies of learning and long-term memory. The other line of research aims to resolve the evolution of important neuronal gene families in vertebrates, especially in relation to the genome doublings at the origin of vertebrates.

Zebrafish reporter gene constructs and single-cell RNA-seq analyses will identify cell populations and genes involved in long-term memory. Spatial transcriptomic analyses will identify key molecules expressed in the brain regions relevant to learning and memory. Molecular interactions between proteins will be studied using cultured cells.

The evolution of neuronal gene families is investigated with a combination of sequence-based phylogenies, species distribution, synteny comparisons across species and analysis of chromosome duplications. The emphasis is on vertebrates, using non-vertebrate deuterostomes and protostomes as outgroups. Special focus is on the gene family evolution in relation to the basal vertebrate genome doublings (tetraploidizations) and the subsequent evolution of novel or more specialized functions.

Personal Profile

Dan Larhammar received his PhD degree in medical science at Uppsala University, Uppsala, Sweden, in 1984. He then studied neuropeptide Y (NPY), a multifunctional neuropeptide with strong stimulatory effect on appetite. After one year as visiting scientist at the Research Institute of Scripps Clinic in La Jolla, California, his work focused on cloning and molecular pharmacology of receptors for NPY. His laboratory discovered several NPY receptors. His research then broadened to exploration of the molecular evolution of eyes in vertebrates and the origin of rods and cones in the retina. Numerous neurotransmitters and hormones and their receptors have been investigated with regard to their evolution in vertebrates. One project concerned the dopamine receptors involved in Parkinson's disease. Since several years he studies the molecular mechanisms for learning and long-term memory. Key players in this machinery are glutamate receptors of the AMPA and NMDA families and several proteins that regulate or are affected by these.

Dan Larhammar was appointed professor of molecular cell biology in the Faculty of Medicine at Uppsala University in 1994. He was elected to the Royal Swedish Academy of Sciences in 2007 and served as president of the Academy 2018-2022. He is a fellow of the International Science Council and a member of the European Academy. He has a strong interest in the distinction of science versus pseudoscience and has also investigated research fraud.

URL:

https://www.gdiist.cn/en/research/team_detail/73

Postdoctoral fellow(2 positions)

Responsibilities

1. Perform evolutionary analyses as outlined above;

2. Actively apply for research projects, such as the National Natural Science Foundation and the China Postdoctoral Science Foundation, collaboratively undertake significant research projects with the group leader, and publish papers in important SCI journals in the related fields;

3. Assist other lab members in conducting related research projects;

4. Complete other tasks assigned by the group leader.

Qualifications

1. PhD in relevant field such biology or bioinformatics (with emphasis on "bio");

2. The candidate should ideally be familiar with the ENSEMBL and NCBI databases and performing protein and nucleotide sequence alignments, calculating phylogenetic trees for protein and gene families, and making synteny comparisons across species;

3. Published research articles containing phylogenetic analyses;

4. Good English reading and writing skills, good communication abilities and a spirit of teamwork.

Benefits

Postdoctoral living allowances will enjoy the overlap of favorable policies from national, provincial, and municipal levels. It will fund for two years. The total personal annual income of salary and living allowance for postdoctoral researchers starts at 520,000 RMB (pre-tax).

Other Beniefits

1. Social Insurance

In accordance with relevant Guangdong Province policies, the institute will pay the pension insurance, medical insurance, unemployment insurance, maternity insurance, work-related injury insurance, and housing provident fund for employees. The employee's personal contribution will be deducted from their monthly salary by the institute. Other benefits and treatment will follow national regulations.

2. Tax Refund Incentive

According to relevant regulations, employees paying personal income tax in the Guangdong-Macao In-Depth Cooperation Zone in Hengqin are eligible for a certain percentage of tax refund benefits.

3. Household Registration and Children's Education

In accordance with relevant regulations, the institute will assist in obtaining Zhuhai/Hengqin household registration and help with the arrangement of children's schooling.

Contact Us

Please provide a complete personal resume, degree certificates, representative research papers, a summary of past research achievements combined into one PDF document, full electronic versions of published papers, and materials proving your academic/professional competence. Candidates who meet the requirements will be scheduled for an interview. Please note that application materials will not be returned, and confidentiality will be maintained by the Guangdong Institute of Intelligence Science and Technology (GDIIST).

Applicants should send their materials to the email address:wangshuang@gdiist.cn. The subject of the email is suggested to described as "Laboratory of Memory and Cognition - Postdoctoral Fellow - Name".

For an introduction to Hengqin, please click the attached "Hengqin Guidebook.pdf".Hengqin Guidebook.pdf

This recruitment notice will remain valid until the positions are filled.

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